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47 ± 33.65 ng/mL) and NGR (23.97 ± 16.77 ng/mL) decreased remarkably with oral administration of the SPN extracts, while GRe showed no significantly difference. Of note, GRg and GRk could not be detected in the plasma. Influence of the processing reduced the systemic exposure levels to GRg , GRb , GRd and NGR . It is the first report of comparative pharmacokinetic study of multiple saponins analysis after oral administration of RPN and SPN extract, which might be helpful for further studies on its steam-processing mechanism. Influence
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