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Conclusion With the developed assay, monitoring of plasma free concentrations may be evaluated as an indicator of pazopanib exposure in patients. © 2020 The Authors.A temporary discontinuation (drug holiday) of high-dose antiresorptive (AR) agents has been proposed to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ). The aim of this systematic review was to answer the question Is high-dose AR drug holiday, at the time of tooth extraction or dentoalveolar surgery, necessary to prevent the development of MRONJ in pati