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Although we attempt to plan the way we live, perhaps the best description of life is from the words of Yogi Berra "It's tough to make predictions, especially about the future." A little over a year ago, I thought my future was predictable; after a fulfilling career, I would enjoy a last decade of research before a comfortable retirement. Then I lost my beloved wife and life partner, Suzanne Eaton to a senseless act of violence, and all assumptions were called into question.Cell cycle mutants in the budding and fission yeasts have played