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Furthermore, with signals of different length, different peak distributions and even from totally different instruments, the proposed method requires minimal user intervention, in which the parameters of the comparing methods should be adjusted for a wide range.Dopamine (DA) is a critical biomarker for a variety of neurological diseases. Methods for simple and rapid DA detection are crucial for clinical diagnosis and treatments for those diseases. In this work, we developed a novel pretreatment-free method for dopamine detection using c