https://www.selleckchem.com/pr....oducts/pkm2-inhibito
Furthermore, we showed that conditional expression of LAMP2A, the key CMA regulator, in dopaminergic (DA) neurons helped maintain mitochondria morphology and protected DA neuronal viability in a rodent PD model. Our work uncovers a critical role of CMA in maintaining proper mitochondria dynamics, and loss of this regulatory control may occur in PD and underlie its pathogenic process.Abbreviations CMA chaperone-mediated autophagy; DA dopaminergic; DNM1L dynamin 1 like; FCCP carbonyl cyanide 4-(trifluoromethoxy) phenylh
Beğen
Yorum Yap
Paylaş
