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05). However, SGLT2 inhibition when combined with dietary counselling led to greater loss of fat-free mass (counselling × medication interaction p = 0.047) and attenuated the rise in high-density lipoprotein cholesterol (counselling × medication interaction p = 0.028). In light of these data and the health implications of decreased fat-free mass, we recommend careful consideration before implementing SGLT2 inhibition as an adjunct to dietary counselling for weight loss in sedentary adults with obesity.Model membrane systems are essential tools for the study