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Proteins, nucleic acids, lipids, and metabolites, a variety of bioactive molecules, are carried and dispersed by EVs, leading to epigenetic and phenotypic shifts in the targeted cells. This underscores the pivotal role of EVs as mediators of both homeostasis and the initiation of disease. The ability of extracellular vesicles (EVs) to navigate the blood-brain barrier (BB, moving from the central nervous system (CNS) to the peripheral bloodstream and bac