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C scheme was found to provide the most accurate prediction of AUC values (r = 0.984) with the target value of 1.9-4.2 μg/ml at steady state to reach the 50-100 μg h/ml criteria of AUC . C with target value of 1.0-2.8 μg/ml can be considered an alternative sampling scheme (r = 0.90 but prediction deviation may exist. C and C sampling scheme also demonstrated good predicting ability of AUC values using PK model. This study provides a clear plan for the implementation of TDM of PB, which is useful for optimizing the dosing regimen and i