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Researchers have suggested that the triglyceride-glucose (TyG) index represents a novel and reliable proxy for insulin resistance (IR). Yet, the association of this element with the risk of end-stage renal disease (ESRD) in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) is presently unknown. Consequently, we investigated the connection between the TyG index and the risk of ESRD in individuals with T2DM and CKD. From January 2013 through December 202