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Additionally, the tumor suppressor protein p53 was also induced in p53 wild type cancer cells.As a large enveloped RNA virus, coronavirus is of considerable medical and veterinary significance, and anticoronavirus treatment is challenging due to its biodiversity and rapid variability. In this study, Au@Ag nanorods (Au@AgNRs) were successfully synthesized by coating AuNRs with silver and were shown for the first time to have activity against the ****tion of porcine epidemic diarrhea virus (PEDV). Viral titer analysis demonstrated that