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Furthermore, lysionotin considerably hampered the neurogenic nociception triggered by intraplantar injections of glutamate and capsaicin, reducing it by 57% and 672%, respectively, at a dosage of 200g/kg. Consequently, lysionotin demonstrated peripheral and central antinociceptive effects, achieved by modulating vanilloid receptors, opioid receptors, and the glutamatergic system. Lysionotin's antinociceptive impact on