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Pulmonary hypertension (PH) has been described in patients treated with leflunomide. The objective of this study was to assess the association between leflunomide and PH. We identified incident cases of PH in patients treated with leflunomide from the French PH registry and through the VIGIAPATH pharmacovigilance program between September 1999 to December 2019. PH aetiology, clinical, functional, radiologic, and haemodynamic characteristics were reviewed at baseline and follow-up. A pharmacovigilance disproportionality analysis using the World