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1±13.6years. There was a significant decrease in PAPs associated with transition from ACEI/ARB to sacubitril/valsartan. The median (interquartile range) pre-treatment and post-treatment change in mean, systolic and diastolic PAPs were -3.6 (-9.8, -0.7) mmHg (P0.001), -6.5 (-15.0, -2. mmHg (P=0.001), and -2.5 (-5.7, -0.7) (P=0.001), respectively. The decrease in PAPs was independent of trans-pulmonary gradient (F(1,16)=0.49, P=0.49). In this retrospective case series, transition from ACEI/ARB to sacubitril/valsartan was associated wi
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