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The MCC/mm was significantly lower in FC biopsies (p 0.01). Sixteen percent of FC samples compared with 60% of RC samples had a high MCC 28/mm (p 0.01). There was no significant difference in positive microbiology culture between FC (21%) and RC (28%) sampling. Rigid and flexible cystoscopy can be used to investigate BPS/IC as recommended by international societies. However, the biopsy method impacts the mast cell count analysis, which can influence diagnosis and management. Therefore, RC would be the optimal investigation.
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