https://www.selleckchem.com/pr....oducts/skf38393-hcl.
The importance of inhibiting the kinases of the DDR pathway for radiosensitizing cancer cells is well established. Cancer cells exploit these kinases for their survival, which leads to the development of resistance towards DNA damaging therapeutics. In this article, the focus is on targeting the key mediator of the DDR pathway, the ATM kinase. A new set of quinoline-3-carboxamides, as potential inhibitors of ATM, is reported. Quinoline-3-carboxamide derivatives were synthesized and cytotoxicity assay was performed to analyze the ef
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