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isk for chronic pain and implementing early interventions. Exercise thermoregulation studies typically control for time of day. The present study assessed whether circadian rhythm independently alters time-dependent changes in core temperature and sweating during exercise at a fixed rate of metabolic heat production (Hprod) during the wake period. Ten men (26±2 y, 76.6±6.3 kg, 1.95±0.10 m) cycled for 60 minutes in 3 combinations of ambient temperature and Hprod (23°C-7.5W.kg, 33°C-5.5W.kg, and 33°C-7.5W.kg) at 2 times of day (AM 0800h,