https://www.selleckchem.com/pr....oducts/trastuzumab-d
No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).Vascular dysfunction is a typical characteristic of aging, but its contributing roles to systemic aging and the therapeutic potential are lacking experimental evidence. Here, we generated a knock-in mouse model with the causative Hutchinson-Gilford progeria syndrome (HGPS) LmnaG609G mutation, called progerin. The Lmnaf/f ;TC mice with progerin expression induced by Tie2-Cre exhibit defective microvasculature an