https://www.selleckchem.com/pr....oducts/cid44216842.h
Mechanistically, a genome-wide CRISPR screen revealed that such a resistance mechanism is elicited by a dual axis GCN2-ATF4 aimed at restoring amino acid levels and MAPK-BCLXL to promote survival. Importantly, pharmacological inhibition of such nodes synergizes with l-asparaginase-mediated asparagine deprivation in ASNS deficient cells suggesting novel potential therapeutic combinations in melanoma.Despite being among the most characterized G protein-coupled receptors (GPCRs), adenosine receptors (ARs) have always been a difficult t
처럼
논평
공유하다
