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Molecular imprinting and nanotechnology were synergistically employed to engineer an innovative nanocoordinator capable of precisely targeting and re-shaping TAMs, thereby enhancing the antitumor efficacy of macrophages via a cascade of effects. A magnetic iron oxide nanoinner core, enveloped by a sialic acid-imprinted shell, characterizes the nanocoordinator. An external magnet triggers the nanocoordinator's rapid accumulation at the tumor