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0 vs. 134.0 days, 0.001; OS 435.0 vs. 295.5 days, 0.001). The SDR was an independent prognostic indicator in the multivariable analysis of PFS ( 0.001) and OS ( = 0.004). In subgroup analyses, among the patients with normal sodium and D-dimer levels, SDR was still a reliable prognostic indicator of PFS and OS in patients with AGC (all ≤ 0.001). This study suggests that the SDR may serve as a prognostic indicator for chemotherapy outcome, PFS and OS for patients with AGC receiving first-line chemotherapy. This study sugge