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Following the spectacular success of molecular genetics in deciphering the genetic code in the 1960s, several of its leading practitioners felt sufficiently emboldened to use their newly acquired skills to move on and study that most enigmatic of biological organs - the brain. Sydney Brenner's approach was to focus on Caenorhabditis elegans, a nematode that is genetically tractable, has a nervous system that generates a rich repertoire of behaviours yet is small enough to allow anatomical reconstructions with ultrastructural precision.