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Our retrospective analysis aimed to ascertain the frequency of central nervous system involvement in diffuse large B-cell lymphoma (DLBCL) patients, along with characterizing its associated risk factors and survival trajectories. Of the 406 patients with diffuse large B-cell lymphoma (DLBCL), 17 (42%) showed evidence of central nervous system (CNS) involvement. This involved 9 (22%) at diagnosis and 8 (approximately 2%) at relap