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To investigate the effect of taxifolin on cisplatin-induced oxidative and proinflammatory optic nerve damage in rats. A total of 18 albino Wistar male rats were assigned into 3 groups, as follows; Group 1 Control group, Group 2 Only cisplatin administered group for 14 days (Cisplatin group), and Group 3 Taxifolin + cisplatin administered group for 14 days (CIS + TAX group). Serum malondialdehyde (MDA), total Glutathione (tGSH), Nuclear Factor-Kappa B (NF-Ƙ, Total Oxidative Status (TOS) and Total Antioxidant Status (TAS) levels were colle