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What is the association between ART conception and treatment parameters and the risk of birth defects? Compared to naturally conceived singleton infants, the risk of a major nonchromosomal defect among ART singletons conceived with autologous oocytes and fresh embryos without use of ICSI was increased by 18%, with increases of 42% and 30% for use of ICSI with and without male factor diagnosis, respectively. Prior studies have indicated that infertility and ART are associated with an increased risk of birth defects but have been limited