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Melasma, a persistent and recurrent pigmentary skin disorder, presents a significant challenge in dermatological treatment. Traditional singular therapies often fail to achieve optimal results and have a high relapse rate. However, recent advancements highlight the promising integration of **picosecond 1064nm laser** and **mesotherapy** as a preferred and effective strategy for managing stubborn cases of melasma. This article delves into the rationale, techniques, and clinical implications of this combined approach. ## The Role of Picosecond 1064nm Laser in Mela
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