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The C HEST score has been validated for predicting AF in the general population or post-stroke patients. We aimed to assess whether this risk score could predict incident AF and other clinical outcomes in heart failure with preserved ejection fraction (HFpEF) patients. A total of 2202 HFpEF patients without baseline AF in the TOPCAT trial were stratified by baseline C HEST score. Cox proportional hazard model and competing risk regression model was used to explore the relationship between C HEST score and outcomes, including incident AF, s