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3 and 6.2 months post infection, the antibody avidity increased significantly (P 0.0001). The newly designed avidity assay in this TOP panel correlated well with a reference Bio-Layer Interferometry avidity assay (R=0.88). The imprecision of the TOP avidity assay was less than 9%. Although TAb and neutralization activity (by SNAb) decreased between 1.3 and 6.2 months post infection, the antibody avidity increased significantly (P less then 0.0001). Subjects recovering from COVID-19 frequently experience persistent respiratory ailmen