https://www.selleckchem.com/pr....oducts/n-acetyl-dl-m
Synaptogenesis is essential in forming new neurocircuits during development, and this is mediated in part by astrocyte-released thrombospondins (TSPs) and activation of their neuronal receptor, α2δ-1. Here, we show that this developmental synaptogenic mechanism is utilized during cocaine experience to induce spinogenesis and the generation of AMPA receptor-silent glutamatergic synapses in the adult nucleus accumbens shell (NAcSh). Using multidisciplinary approaches including astrocyte Ca imaging, genetic mouse lines, vira
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