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Our findings reveal a novel mechanism that TRIM21 restricts HBV ****tion through targeting HBx-Smc5/6 pathway, which may have an implication in the future TRIM21-based therapeutic application. In humans, functional magnetic resonance imaging (fMRI) cannot be used to its full potential to study the effects of deep-brain stimulation (DBS) on the brain due to safety reasons. Application of DBS in small animals is an alternative, but was hampered by technical limitations thus far. We present a novel setup that extends the range of avail
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