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Both models were evaluated in the remaining 249 cases. RESULTS All hemodynamic parameters were significantly different for the varying flow conditions (p less then 0.001). Both the flow-independent "response" model A and the flow-dependent model B performed well with areas under the receiver operating characteristic curve of 0.8182 and 0.8174 ± 0.0045, respectively. CONCLUSIONS The influence of inter- and intra-patient flow variations on computed hemodynamics can be taken into account in multivariate aneurysm rupture prediction models