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Ciprofloxacin is ineffective against S. pneumoniae. Moxifloxacin lacks sufficient activity against Pseudomonas aeruginosa but is effective in treating anaerobes (along with delafloxacin). Delafloxacin is the only quinolone effective against methicillin-resistant S. aureus (MRSA).Hemophagocytic lymphohistiocytosis (HLH) is a devastating, hyper-inflammatory condition that results in multi-organ failure and death. The systemic inflammation that characterizes the disease is the result of inappropriate and dysregulated activation of natural