https://cnqxantagonist.com/ame....lioration-involving-
The hybrid possessing the same substitution pattern as CA-4 demonstrated superior potency and selectivity relative to Dis C, but its overall activity was inferior to CA-4. The novel analog's interference with tubulin assembly, at the colchicine site, disrupted interphase microtubules, ultimately inducing multipolar spindles, causing a cell cycle block, and prompting apoptosis in HeLa cells. It also hindered the establishment of colonies and the movement of
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