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We aimed to explore the consequences of SCO on GC-mediated lipolysis. Mature adipocytes, pre-treated with either a control vehicle or SCO, were subsequently exposed to either the synthetic glucocorticoid dexamethasone (DEX) or tumor necrosis factor-alpha (TNF). Lipolysis was assessed by analyzing the collected medium for glycerol and fatty acids. A study was conducted to assess the expression levels of several lipolytic genes and proteins,