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ntitative MRI protocols, and to transition MRI from a qualitative imaging technique to a precise metrology with documented accuracy and uncertainty. To assess the diagnostic test accuracy of the component-resolved diagnosis device ImmunoCAP ISAC, compared with oral food challenge. Systematic review reported according to the PRISMA-DTA recommendations. Medline, Embase and Cochrane Library databases were searched from inception to May 2019 and updated in March 2021. We included diagnostic test accuracy studies comparing ISAC