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1 µg kg-1 was administered when tachycardia, hypertension or movement ("conventional signs" was observed. Data for 66 patients (27 with known hypertension) were analysed. In the CARDEAN group, (a) the dose of sufentanil was higher (control 0.46 µg kg-1 100 min-1, CARDEAN 0.57 µg kg-1 100 min-1, p = 0.016), (b) the incidence rates of tachycardia and untoward events were lower (respectively - 44%; control 2.52 events 100 min-1 [1.98-3.22]; CARDEAN 1.42 [1.03-1.96], p = 0.005, hazard ratio 0.56; movement, muscular contraction, or coughin
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