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Due to their low abundance, the negative impact of mutations on the response to TKI remains to be confirmed in larger studies. Detection of KRAS mutations in cell-free DNA of EGFR mutant NSCLC patients at progression after first or second generation EGFR TKI is a rare event. Due to their low abundance, the negative impact of KRAS mutations on the response to EGFR TKI remains to be confirmed in larger studies.Cancer is a set of complex pathologies that has been recognized as a major public health problem worldwide for decades. A myriad o