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Patients scoring below -95798 (n=27) exhibited a significantly longer bPFS duration following NHT treatment (P=0.00025). Through this study, we developed a novel predictive transcriptomic signature which potentially can guide the effective selection of neoadjuvant therapies in LAPCa and may offer precise guidance for future personalized adjuvant treatments. The Ethics Committee of Shanghai Jiao Tong University's Renji Hospi