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DCT loss of function in zebrafish embryos elicited hypopigmentation both in melanophoresand RPE cells. DCT is the gene for a new type of oculocutaneous albinism that we propose to name OCA8. DCT is the gene for a new type of oculocutaneous albinism that we propose to name OCA8. Pregnancy loss ranging from spontaneous abortion (SA to stillbirth can result from monogenic causes of Mendelian inheritance. This study evaluated the clinical application of exome sequencing (ES) in identifying the genetic etiology for pregnancy loss. A cohort