https://www.selleckchem.com/pr....oducts/bms-986397.ht
The analyses led us to suggest a mechanism of protein-ligand binding that might explain the activity of the compounds.Immune functions decline as we age, while the incidence of cancer rises. The advent of immune checkpoint blockade (IC has not only revolutionized cancer therapy, but also spawned great interest in identifying predictive biomarkers, since only one third of patients show treatment response. The aging process extensively affects the adaptive immune system and thus T cells, which are the main target of ICB. In this revi