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In this review, we summarize the current understanding of UPS activity during Drosophila and vertebrate ocular development, with a major focus on recent findings correlating Siah E3 ligase activity with two major developmental stages of vertebrate ocular development, retinal morphogenesis and photoreceptor specification and survival. Little is known about the neurologic health needs of ****ual and gender minority (SGM) individuals, and existing research indicates health care disparities for this group. To describe the current state of s