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In addition, p65 overexpression counteracted the effect of miR-361 in human and mice HSCs' biological processes. These findings reveal a latent mechanism underlying p65 modulation by miR-361 which is capable of initiating HSC growth and migration. miR-361 is potentially functioning as a potent marker for HBV-relevant HCC development or liver fibrosis (LF) progression. miR-361 is potentially functioning as a potent marker for HBV-relevant HCC development or liver fibrosis (LF) progression.Aging is a major risk factor for various eye diseases, such as catarac