https://www.selleckchem.com/products/Taurine.html
Numerous physiological functions rely on distinguishing temperature through temperature-sensitive transient receptor potential channels (thermo-TRPs). Although the function of thermo-TRPs has been studied extensively, structural determination of their heat- and cold-activated states has remained a challenge. Here, we present cryo-EM structures of the nanodisc-reconstituted wild-type mouse TRPV3 in three distinct conformations closed, heat-activated sensitized and open states. The heat-induced transformations of TRPV3 are accompanied by
Like
Comment
Share
