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A rare and highly aggressive intraocular tumor, uveal melanoma, suffers from a poor prognosis and has limited treatment alternatives. Recent scientific endeavors have unveiled the role of the PI3K/AKT/mTOR pathway in the formation and advancement of UVM. To understand the potential mechanism of PI3K/AKT/mTOR pathway-related genes (PRGs) in UVM, we aimed to construct a novel prognostic risk model. Unsupervised clustering procedures, applied to 14 PRGs profiles, d