https://neurosignaling.com/ind....ex.php/treatments-fo
The expanding TCR CDR3s exhibited an enrichment of sequences functionally annotated as specific to SARS-COV-2. The expanding T cell receptors recognized epitopes that displayed a high degree of conservation amongst SARS-CoV-2 strains, a characteristic not observed in circulating human coronaviruses. Pre-pandemic repertoires frequently displayed a high prevalence of expanding CDR3s. The preinfection naive repertoire contained a significant proportion of early response TCRs, speci
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