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The levels of ERS, Nrf2, and their downstream mRNAs and proteins were quantified via qRT-PCR and Western blot analysis. Cognitive impairment in mice arises from the interaction of CIH and SF; this impairment is ameliorated by sulforaphane (SFN), which acts as an Nrf2 agonist; conversely, elimination of Nrf2 leads to an intensification of the cognitive decline. Following the impact of CIH and SF, neurons displayed a decline in Nissl
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