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To investigate the appropriate timing of adaptive radiotherapy (ART) for high-grade glioma. Ten patients with high-grade gliomas were selected and underwent CT/MRI (CT /MRI , CT /MRI , CT /MRI , and CT /MRI ) scans before RT and during 10-, 20- and 30-fraction RT, and the corresponding RT plans (plan , plan , plan and plan ) were made. The dose of the initial plan (plan ) was projected to CT2 and CT3 using the image registration technique to obtain the projection plans (plan and plan ) and by superimposing the doses to obtain the ART plan