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The heightened expression of Oryza sativa HPPD in rice and A. thaliana plants, correspondingly, produced a strong level of tolerance to the effects of cypyrafluone in both situations. Molecular docking studies suggest a strong interaction between cypyrafluone and the active site of HPPD, forming a bidentate complex with the Fe2+ atom. The oxygen atoms showed distances of 26 and 27 Angstroms from the Fe2+ ion. A binding energy of -80 kcal/mol was found. An investigation of an
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