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Subsequently, methionine restriction has proven effective in countering various cancers in both in vitro and in vivo situations. Methionine restriction acts to halt the advancement of cancer cells during the S/G2 stage of their cell cycle. Methionine restriction synergistically enhances the efficacy of cytotoxic agents targeting the S/G2 phase. This heightened efficacy stems from the S/G2-phase stagnation of cancer cells, in contrast to the normal
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