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7 ± 225.4 ng.hr/ml). There was a significant variation in Cmax and AUC in three ABCB1 genotyping groups as well. CONCLUSION Gender difference and ABCB1 gene (encoding P-glycoprotein) polymorphisms have a significant impact on the pharmacokinetics of azithromycin as they contribute to inter-individual variability in therapeutic response.Mesenchymal stem/stromal cells (MSCs) have been identified in almost all adult human tissues and been used in numerous clinical trials for a variety of diseases. Studies have shown that MSCs would undergo cellular senescence