https://www.selleckchem.com/pr....oducts/Tie2-kinase-i
Results revealed that , , and displayed promising inhibition in cisplatin-resistant cell lines in comparison to parent cells in terms of both resistance factor (RF) and IC values. Moreover, proved to be most active compound in both parent and resistant cell lines with IC values 15.57 µM and 11.52 µM respectively. Our docking studies demonstrated that compounds , , and exhibited significant binding affinity with multiple protein targets of the signaling cascade. Anticancer activities of compounds , , and in cisplatin-resist
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